Doripenem intermediate

Doripenem intermediate - Names and Identifiers

Name	1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)-
Synonyms	Doripenem intermediate doripenem intermediate? DoripeneM InterMediates (2S,trans)-4-Nitrobenzyl 2-(hydroxymethyl)-4-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate (4-nitrophenyl)methyl (2S,4R)-2-(hydroxymethyl)-4-methylsulfonyloxypyrrolidine-1-carboxylate (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester (2S,4R)-2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)methyl ester 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)- (2S,4R)-2-(Hydroxymethyl)-4-[(Methylsulfonyl)Oxy]-1-Pyrrolidinecarboxylic Acid,(4-Nitrophenyl)Methyl Ester (Doripenem Side-Chain Intermediate) (2S,4R)-2-(hydroxyMethyl)-4-[(Methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)Methyl ester (DoripeneM side-chain interMediate) (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester[(4-nitrophenyl)Methyl] ester, (2S,4R)-
CAS	127626-37-3
EINECS	1533716-785-6

Doripenem intermediate - Physico-chemical Properties

Molecular Formula	C14H18N2O8S
Molar Mass	374.37
Density	1.51
Melting Point	113-116℃
Storage Condition	2-8°C
Sensitive	IRRITANT
MDL	MFCD18800446

Doripenem intermediate - Introduction

(2S,4R) 1-pyrrolidinecarboxylic acid is an organic compound whose chemical formula is C6H9NO2. The following is a description of the properties, uses, preparation and safety information of (2S,4R) 1-pyrrolidine carboxylic acid:

Nature:
-Appearance: Colorless or white crystalline powder;
-Solubility: soluble in water and common organic solvents;
-Melting point: about 150-155°C.

Use:
-as a drug intermediate:(2S,4R) 1-pyrrolidine carboxylic acid can be used to synthesize a variety of drug intermediates, such as antitumor drugs, antiviral drugs, antiepileptic drugs, etc;
-as a chiral catalyst:(2S,4R) 1-pyrrolidine carboxylic acid can catalyze a variety of chiral organic reactions, such as asymmetric synthesis, Friedel-Crafts reaction, etc.

Preparation Method:
The preparation method of (2S,4R) 1-pyrrolidine carboxylic acid can be achieved by the following steps:
1. reacting 4-amino -1-phenyl -2-carbonyl pyrrolidine with p-iodomethane to obtain 4-(methylamino)-1-phenyl -2-carbonyl pyrrolidine (4-methyl amino phenyl pyrrolidone);
2. 4-Methylaminophenylpyrrolidone is reduced with a base to obtain (2S,4R) 1-pyrrolidinecarboxylic acid.

Safety Information:
The specific safety and toxicity information for (2S,4R) 1-Pyrrolidine carboxylic acid may be affected by factors such as the manufacturing process, so it is best to follow the following safety precautions when using or coming into contact with this compound:
-Wear appropriate personal protective equipment, such as lab gloves and goggles, when handling the compound;
-Avoid inhaling the dust or smell of the compound and ensure that you work in a well-ventilated area;
-During use or storage, comply with relevant safety procedures to avoid unsafe reactions with other substances.

Last Update：2024-04-09 21:32:37